Remote ischaemic preconditioning of the heart: remote questions, remote importance, or remote preconditions?
نویسندگان
چکیده
منابع مشابه
Cardioprotection by remote ischaemic preconditioning.
Perioperative myocardial infarction is a leading cause of morbidity and mortality after major non-cardiac surgery. Pharmacological agents such as beta-blockers may reduce the risk but are associated with side-effects and may be contra-indicated in some patients. Basic scientific experiments and preliminary clinical trials in humans suggest that remote ischaemic preconditioning (RIPC), where bri...
متن کاملRemote ischaemic preconditioning: closer to the mechanism?
Brief periods of ischaemia followed by reperfusion of one tissue such as skeletal muscle can confer subsequent protection against ischaemia-induced injury in other organs such as the heart. Substantial evidence of this effect has been accrued in experimental animal models. However, the translation of this phenomenon to its use as a therapy in ischaemic disease has been largely disappointing wit...
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Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were ...
متن کاملTime for reassessment of remote ischaemic preconditioning.
Ischaemia–reperfusion (IR) injury is a recognized cause of perioperative morbidity and mortality affecting a wide range of surgical procedures, but particularly cardiovascular surgery. Over the past 30 years a large body of published animal and clinical research has suggested that ischaemic preconditioning (IPC), consisting of a limited ischaemic insult applied before the expected major ischaem...
متن کاملRemote Ischemic Preconditioning
Ischemic Preconditioning Ischemic preconditioning is a widely accepted concept, first introduced in 1986 by Murray et al,1 who showed in an animal experiment that multiple brief periods (5 min) of coronary artery occlusion dramatically reduced infarct size because of the subsequent sustained coronary occlusion. Numerous reports have followed and supported the concept. The mechanism of ischemic ...
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ژورنال
عنوان ژورنال: Basic Research in Cardiology
سال: 2011
ISSN: 0300-8428,1435-1803
DOI: 10.1007/s00395-011-0187-7